I hope that with some of the functions can be split off with the use of script extenders (i.e. separating the workshop action from the change POV action, among others) and that others can be rebound (changing ENTER/TAB for OK/Cancel to Q/E, or something similar). I know doing the latter was popular with Skyrim, which suffered from many of the same issues, so I'm pretty hopeful. As much as I hate it, I still don't think I'm going to use a controller at this point. The shooty bang bang segments just work so much better with keyboard/mouse, to me anyway.
The part that annoys the hell out of me is that it seems like Bethesda has learned nothing from the savage criticisms of their user interfaces since Oblivion. Things have just been getting worse and worse over the years. I don't understand how they can be satisfied with being both the best (ridiculous modding support, fully usable console, etc) and worst (awful controls and UI, ignoring UX feedback, etc) PC game publishers. I can't even imagine the latter being all that hard to fix, either. Even companies as stubborn as Apple have hired from the community to improve their products (iOS's notification center and popups improved drastically as a result of this).