So, after using Chrome for my default browser for a while, I've noticed a couple rather annoying aspects.
When the download history gets too large, it starts to take a long time between when you clicked "download this link" to when the save file dialog appears.
Chrome can't properly handle SVG files taller than the screen (it doesn't make a scroll bar appear, making it impossible to scroll down and see the rest of the image).
And contrary to common belief, right clicking and spawning a new tab doesn't spawn a new process every time. any link you followed from a website into a new tab will be in that process, until you hit the maximum (90, IIRC). The only way to spawn a new process is to make a new empty tab.
Also, I think this is only in the current dev build, but if you download something (bringing up that download bar at the bottom) and navigate away from the page, you can no longer close the bar or interact with any of the items on it at all until you start another download on a tab you have open, at which point it erases the bar and starts a new one. In fact, if you closed the tab while something was downloading, the bar doesn't even get updated. However, the downloads tab still works, so you can still check/open your downloads. It's just a bit of a pain in the ass.
Not to mention I can'd find the application specific volume bar for chrome (or it's plugins). I dunno whether that's a problem with chrome or Vista, but when I have my main volume at max (which is REALLY FUCKING LOUD), and all my application specific bars really low, and I decide to watch a youtube video, I get aurally assaulted, thanks to not having an application specific volume bar.
Aside form those, I really enjoy using Chrome. It's a very responsive and nicely designed browser, and it easily meets my needs. sure, it's not as extendable as firefox, with the billion or so addons that firefox has, but if you want a nice, responsive browser with a light interface, it's definitely worth trying (for an extended period of time).
Now, there are a couple things I absolutely love about it that I feel deserve mention here, since I don't want this to be a totally negative post.
The "press tab to search" feature. I absolutely LOVE that feature. If I want to search wikipedia, all I have to do is type w into my location bar, and then hit tab, and type in my search. It works for isohunt, facebook, youtube and probably a number of others as well.
The simplified interface is one of the things I really love about it. Somehow the guys at google managed to break all those menus you usually have into 2 buttons. One for page specific menus and one for Chrome specific stuff. and they don't have a gigantic number of entries in them either. Despite the sophisticated back end, Chrome is built upon the ideal of simplifying everything. Especially the interface.
Application shortcuts. Goddamn I love this feature. With a few simple clicks, I have a shortcut to a very lightweight Gmail link right on my start menu, and it even runs in a stripped down version of Chrome. It runs without any of the menus or other clutter that comprise the interface and is straight to the point. It opens up my Gmail and works perfectly. If I need to click a link, it opens a new window of chrome for me on top of my Gmail window, leaving it separate even from the tabs in the current window. To me, this is judicious use of windows in the "new window or new tab" setting we now have.
Moving tabs around, from window to window, or into an entire new window, or anything else you might want to do with tabs is insanely easy. The only thing missing is a "re-open last closed tab" entry in the right click menu on tabs...