My 20s (particular around the 23-28 range) were pretty rough. Not sure how much of it was self-inflicted and how much of it was due to external influences, but there was definitely a bit of both in there.
I'm a bit more relaxed nowadays and actually have at least a modicum of self-esteem. Not sure if it's age, maturity, new friends, or what, but things feel a lot less fucked up nowadays.