E is fantastic, but like everything, all in moderation. Yes, if you roll 5 pills a day for a month you'll probably get VERY fucked up. If you did that much acid for a month, you'd probably get fucked up. DXM same amount of time? Very fucked up. Pot?..... well nevermind.
I wouldn't even roll every weekend, but once in a while it's a great experience! I've yet to do shrooms or Acid, but I'm looking forward to trying this summer. My dealer (MJ) doesn't roll with anything but his MMJ shit from california (Trainwreck), which I'm fine with, I love the shit.